The antidepressant-like action of Delta (-THC) and CBC was also confirmed in the TST. As you can see, research on THC for depression is limited and all focuses on delta-9-THC. Anecdotal reports often confirm that delta-8 has significant benefits for improving mood, but more research is needed to understand how it differs, if at all, from traditional THC therapies. There are around 400 chemical compounds in an average cannabis plant.
The four main ones are delta-9 tetrahydrocannabinol (delta-9-THC), cannabidiol (CBD), delta-8-tetrahydrocannabinol and cannabinol. All but CBD are psychoactive (known to affect brain function). Even if there are no comparative studies on the pharmacokinetics of THC in rats with humans, studies that evaluated the concentration of THC and its metabolites after i. Similarly, adults exposed to THC had decreased serotonin activity, suggesting that THC may induce vulnerability in the monoaminergic system, even if the behavioral effects are more pronounced in adolescents.
Following these recent interpretations, the decrease in swimming latency observed after exposure to THC in adolescents can be interpreted as a survival or resilience strategy, even if more studies are needed to better characterize the behavioral effects of THC on hopeless-like behaviors. Chronic exposure to THC in adolescents during adolescence reduced the stimulating activity of 5-HT to the same extent as chronic exposure to THC in adults (B).
